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Conjugation of a fatty acid chain via hydrophilic linkers to lysine residue at the C20 position prolongs its half-life and enables onceweekly subcutaneous administration [62]
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Once daily injection of seipin knockout mice with liraglutide for 14 days led to significant improvements in hepatomegaly associated with steatosis and reduced markers of liver fibrosis
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This timing reset is critical: it allows GLP-1 receptor sensitivity to normalize before dual-receptor activation begins
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